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Role of drug exposure in aphthous ulcers: a case-control study.

Authors :
Boulinguez S
Reix S
Bedane C
Debrock C
Bouyssou-Gauthier ML
Sparsa A
Le Brun V
De Vencay P
Bernard P
Bonnetblanc JM
Source :
The British journal of dermatology [Br J Dermatol] 2000 Dec; Vol. 143 (6), pp. 1261-5.
Publication Year :
2000

Abstract

Background: Drug-induced aphthous ulcers have been the subject of several isolated and heterogeneous case reports for the last three decades.<br />Objectives: To perform a case-control study to evaluate the risks linked to drug exposure in aphthous ulcers.<br />Methods: Eighty patients with typical clinical patterns of aphthous ulcers and 152 control patients who had had consultations for skin tumours were studied. A standardized questionnaire, concerning clinical features, life-style and medications taken during the last month, was completed for each patient.<br />Results: Case patients had a much higher intake of medications than control patients, respectively, 5.1 and 2. 8 medications per patient (P < 0.0001). Multivariate paired analysis showed an association between aphthous ulcers and two classes of drugs: non-steroidal anti-inflammatory drugs (P < 0.001) and beta-blockers (P = 0.002). Smoking could have a protective effect against aphthous ulcers (P < 0.001).<br />Conclusions: Previous case reports and the results of this study suggest a real link between beta-blockers and aphthous ulcers. Our study did not confirm a role of other drugs but a few interesting case reports with positive reintroduction have to be considered. These results could be beneficial for patients, as healing may occur when the incriminated drug is discontinued.

Details

Language :
English
ISSN :
0007-0963
Volume :
143
Issue :
6
Database :
MEDLINE
Journal :
The British journal of dermatology
Publication Type :
Academic Journal
Accession number :
11122030
Full Text :
https://doi.org/10.1046/j.1365-2133.2000.03898.x