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Role of drug exposure in aphthous ulcers: a case-control study.
- Source :
-
The British journal of dermatology [Br J Dermatol] 2000 Dec; Vol. 143 (6), pp. 1261-5. - Publication Year :
- 2000
-
Abstract
- Background: Drug-induced aphthous ulcers have been the subject of several isolated and heterogeneous case reports for the last three decades.<br />Objectives: To perform a case-control study to evaluate the risks linked to drug exposure in aphthous ulcers.<br />Methods: Eighty patients with typical clinical patterns of aphthous ulcers and 152 control patients who had had consultations for skin tumours were studied. A standardized questionnaire, concerning clinical features, life-style and medications taken during the last month, was completed for each patient.<br />Results: Case patients had a much higher intake of medications than control patients, respectively, 5.1 and 2. 8 medications per patient (P < 0.0001). Multivariate paired analysis showed an association between aphthous ulcers and two classes of drugs: non-steroidal anti-inflammatory drugs (P < 0.001) and beta-blockers (P = 0.002). Smoking could have a protective effect against aphthous ulcers (P < 0.001).<br />Conclusions: Previous case reports and the results of this study suggest a real link between beta-blockers and aphthous ulcers. Our study did not confirm a role of other drugs but a few interesting case reports with positive reintroduction have to be considered. These results could be beneficial for patients, as healing may occur when the incriminated drug is discontinued.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Child
Child, Preschool
Female
Humans
Male
Middle Aged
Multivariate Analysis
Adrenergic beta-Antagonists adverse effects
Analgesics, Opioid adverse effects
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Stomatitis, Aphthous chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0007-0963
- Volume :
- 143
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The British journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 11122030
- Full Text :
- https://doi.org/10.1046/j.1365-2133.2000.03898.x