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Involvement of transglutaminase in the receptor-mediated endocytosis of mouse peritoneal macrophages.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2000 Dec; Vol. 23 (12), pp. 1511-3. - Publication Year :
- 2000
-
Abstract
- We investigated the effect of extracellular Ca2+ on the uptake of immunoglobulin G (IgG)-coated normal sheep red blood cells (SRBC) by the mouse peritoneal macrophages. The uptake of SRBC was dose dependently enhanced by Ca2+ concentration. We also investigated the effect of ryanodine on the uptake of SRBC. Ryanodine showed approximately 15% inhibition of the uptake. The activity of transglutaminase (TGase) in the cytosolic fraction of macrophages was enhanced as the Ca2+ concentration increased. The uptake of SRBC decreased by the addition of histamine, a TGase inhibitor. These results suggest that TGase is involved in the receptor-mediated endocytosis system of mouse peritoneal macrophages.
- Subjects :
- Animals
Calcium pharmacology
Endocytosis drug effects
Erythrocytes immunology
Erythrocytes metabolism
Histamine pharmacology
Immunoglobulin G immunology
Macrophages, Peritoneal drug effects
Macrophages, Peritoneal enzymology
Macrophages, Peritoneal immunology
Male
Mice
Mice, Inbred C3H
Sheep
Transglutaminases antagonists & inhibitors
Endocytosis physiology
Macrophages, Peritoneal physiology
Receptors, Fc physiology
Transglutaminases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0918-6158
- Volume :
- 23
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 11145187
- Full Text :
- https://doi.org/10.1248/bpb.23.1511