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The effect of aging and interval between primary and secondary treatment in two-stage carcinogenesis on mouse skin.
- Source :
-
Cancer research [Cancer Res] 1975 Mar; Vol. 35 (3), pp. 502-5. - Publication Year :
- 1975
-
Abstract
- Two-stage carcinogenesis experiments on mouse skin (female ICR/Ha Swiss mice) were done by initiating mice at three age levels (6, 44, and 56 weeks) and promoting after a 2-week interval. In another series, mice were initiated at age 6 weeks, and three time intervals (2, 36, and 56 weeks) were used between initiation and promotion. The initiating agent was 7, 12-dimethylbenz(a)anthracene and the promoting agent was phorbol myristate acetate in all experiments. The results showed a general decrease in tumor production with increasing age at the time of promotion. However, the initiating effect persisted even when the interval between initiation and promotion was 56 weeks.
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 35
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 1116119