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Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia.
- Source :
-
Psychiatry research [Psychiatry Res] 2000 Dec 27; Vol. 97 (2-3), pp. 101-6. - Publication Year :
- 2000
-
Abstract
- Abnormalities of serotonin synthesis and metabolism may be associated with suicidality. The serotonin transporter gene (5-HTT) is one of the important genes involved in the regulation of serotonin neurotransmission. We examined the association of suicidal behavior in Chinese schizophrenic patients with a functional polymorphism of the promoter region of the 5-HTT gene (5-HTTLPR). The 5-HTTLPR genotype was determined by polymerase chain reaction for 76 suicidal and 262 non-suicidal patients with a diagnosis of schizophrenia (DSM-IV criteria). All subjects were unrelated to each other, and all were Chinese. There was no significant genotypic or allelic association of the 5-HTTLPR polymorphism with history of attempted suicide. From our results, this 5-HTTLPR polymorphism is unlikely to have a major effect on suicidal behavior in Chinese patients with schizophrenia.
- Subjects :
- Adult
Alleles
China ethnology
Female
Humans
Male
Middle Aged
Polymerase Chain Reaction
Promoter Regions, Genetic genetics
Schizophrenic Psychology
Serotonin Plasma Membrane Transport Proteins
Singapore epidemiology
Suicide, Attempted psychology
Carrier Proteins genetics
Gene Expression genetics
Membrane Glycoproteins genetics
Membrane Transport Proteins
Nerve Tissue Proteins
Polymorphism, Genetic genetics
Schizophrenia ethnology
Schizophrenia genetics
Serotonin biosynthesis
Serotonin genetics
Suicide, Attempted ethnology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 97
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 11166082
- Full Text :
- https://doi.org/10.1016/s0165-1781(00)00229-8