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Antitubercular activity of triterpenoids from Lippia turbinata.
- Source :
-
Journal of natural products [J Nat Prod] 2001 Jan; Vol. 64 (1), pp. 37-41. - Publication Year :
- 2001
-
Abstract
- Assay-guided fractionation of the antitubercular MeOH-CH(2)Cl(2) extract obtained from Lippia turbinata led to the isolation of four novel triterpenoids-3beta,25-epoxy-3alpha,21alpha-dihydroxy-22beta-(3-methylbut-2-en-1-oyloxy)olean-12-ene-28-oic acid (1); 3beta,25-epoxy-3alpha,21alpha-dihydroxy-22beta-angeloyloxyolean-12-ene-28-oic acid (2); 3beta,25-epoxy-3alpha,21alpha-dihydroxy-22beta-tigloyloxyolean-12-ene-28-oic acid (3); and 3beta,25-epoxy-3alpha-hydroxy-22beta-(2-methylbutan-1-oyloxy)olean-12-ene-28-oic acid (4)-together with the known triterpenoids lantanilic acid (5), camaric acid (6), lantanolic acid (7), and rehmannic acid (8). The MIC values of 1-8 for growth inhibition of Mycobacterium tuberculosis were determined in the radiorespirometric BACTEC system.
- Subjects :
- Animals
Antitubercular Agents chemistry
Antitubercular Agents toxicity
Chile
Chlorocebus aethiops
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Mycobacterium tuberculosis drug effects
Plant Extracts chemistry
Plant Extracts pharmacology
Plant Extracts toxicity
Triterpenes chemistry
Triterpenes toxicity
Vero Cells
Antitubercular Agents pharmacology
Plants, Toxic chemistry
Triterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 64
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 11170663
- Full Text :
- https://doi.org/10.1021/np000267b