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Noninvasive diagnosis of allograft vascular disease after heart transplantation.
- Source :
-
Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2001 Jan; Vol. 76 (1), pp. 29-42. - Publication Year :
- 2001
-
Abstract
- Objective: To determine the predictive values of noninvasive tests for the detection of allograft vascular disease.<br />Methods: We studied 39 patients with mean ages of 48+/-13 years and a follow-up period of 86+/-13 months. The diagnosis of allograft vascular disease was made by cine-coronary arteriography, and it was considered as positive if lesions existed that caused > or =50% obstruction of the lumen. Patients underwent 24h Holter monitoring, thallium scintigraphy, a treadmill stress test, and dobutamine stress echocardiography. Sensitivity, specificity, and positive and negative predictive values were determined in percentages for each method, as compared with the cine-coronary arteriography results.<br />Results: Allograft vascular disease was found in 15 (38%) patients. The Holter test showed 15.4% sensitivity, 95.5% specificity. For the treadmill stress test, sensitivity was 10%, specificity was 100%. When thallium scintigraphy was used, sensitivity was 40%, specificity 95.8%. On echocardiography with dobutamine, we found a 63.6% sensitivity, 91.3% specificity. When the dobutamine echocardiogram was associated with scintigraphy, sensitivity was 71.4%, specificity was 87%.<br />Conclusion: In this group of patients, the combination of two noninvasive methods (dobutamine echocardiography and thallium scintigraphy) may be a good alternative for the detection of allograft vascular disease in asymptomatic patients with normal ventricular function.
- Subjects :
- Adult
Coronary Disease diagnostic imaging
Echocardiography
Electrocardiography, Ambulatory
Follow-Up Studies
Humans
Linear Models
Middle Aged
Predictive Value of Tests
Radionuclide Angiography
Sensitivity and Specificity
Transplantation, Homologous
Coronary Disease diagnosis
Heart Transplantation adverse effects
Subjects
Details
- Language :
- English; Portuguese
- ISSN :
- 0066-782X
- Volume :
- 76
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Arquivos brasileiros de cardiologia
- Publication Type :
- Academic Journal
- Accession number :
- 11175482
- Full Text :
- https://doi.org/10.1590/s0066-782x2001000100004