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Cell biology. Actin' up with Rac1.
- Source :
-
Science (New York, N.Y.) [Science] 2000 Dec 08; Vol. 290 (5498), pp. 1902-3. - Publication Year :
- 2000
-
Abstract
- The elegant architecture of photoreceptor cells in the retina is dependent on organization of the actin cytoskeleton during eye development. But what drives this organization? In an equally elegant Perspective, Colley explains new findings in fruit flies (Chang and Ready) that point to the photopigment rhodopsin and its signaling molecule the Rho GTPase Drac1 as the orchestrators of actin organization and the consequent assembly of the sensory membrane in the photoreceptor cell.
- Subjects :
- Actin Cytoskeleton metabolism
Amino Acid Motifs
Animals
Drosophila
Enzyme Activation
Humans
Models, Biological
Morphogenesis
Photoreceptor Cells, Invertebrate cytology
Photoreceptor Cells, Invertebrate metabolism
Retina growth & development
Retina ultrastructure
Retinitis Pigmentosa genetics
Retinitis Pigmentosa metabolism
Retinitis Pigmentosa pathology
Rhodopsin chemistry
Signal Transduction
Actin Cytoskeleton ultrastructure
Drosophila Proteins
Photoreceptor Cells, Invertebrate growth & development
Photoreceptor Cells, Invertebrate ultrastructure
Rhodopsin metabolism
rac GTP-Binding Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 290
- Issue :
- 5498
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 11187046
- Full Text :
- https://doi.org/10.1126/science.290.5498.1902