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Synthfsis of bis(aziridinyl)phosphinyl-N-hydroxyurethane derivatives as antineoplastic agents.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 1975 Feb; Vol. 18 (2), pp. 195-8. - Publication Year :
- 1975
-
Abstract
- Several new "dual antagonists" were synthesized in which the 2,2-dimethyl (or ring C unsubstituted) aziridine phosphinyl function is linked to N-hydroxyurethane rather than the urethane moiety. Three of the new compounds showed very high activities against leukemia L1210 in mice.
- Subjects :
- Alkylating Agents chemical synthesis
Animals
Antineoplastic Agents therapeutic use
Antineoplastic Agents toxicity
Aziridines therapeutic use
Aziridines toxicity
Drug Evaluation, Preclinical
Female
Lethal Dose 50
Leukemia L1210 drug therapy
Mice
Mice, Inbred Strains
Phosphines chemical synthesis
Phosphines therapeutic use
Phosphines toxicity
Urethane chemical synthesis
Urethane therapeutic use
Urethane toxicity
Antineoplastic Agents chemical synthesis
Aziridines chemical synthesis
Azirines chemical synthesis
Urethane analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 1120987
- Full Text :
- https://doi.org/10.1021/jm00236a019