(1-oxo-2-substituted-5-indanyloxy)acetic acids, a new class of potent renal agents possessing both uricosuric and saluretic activity. A reexamination of the role of sulfhydryl binding in the mode of action of acylphenoxyacetic acidsaluretics.

Subjects

Subjects :

Acetates chemical synthesis
Animals
Chlorides urine
Diuresis drug effects
Diuretics pharmacology
Dogs
Female
Glycolates chemical synthesis
Glycolates pharmacology
Indans pharmacology
Male
Pan troglodytes
Potassium urine
Rats
Sodium urine
Stereoisomerism
Structure-Activity Relationship
Uricosuric Agents pharmacology
Diuretics chemical synthesis
Indans chemical synthesis
Indenes chemical synthesis
Uricosuric Agents chemical synthesis

Details

Language :

English

ISSN :

0022-2623

Volume :

18

Issue :

2

Database :

MEDLINE

Journal :

Journal of medicinal chemistry

Publication Type :

Academic Journal

Accession number :

1120997

Full Text :

https://doi.org/10.1021/jm00236a031