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Clear cell sarcoma shows immunoreactivity for microphthalmia transcription factor: further evidence for melanocytic differentiation.
- Source :
-
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2001 Jan; Vol. 14 (1), pp. 6-9. - Publication Year :
- 2001
-
Abstract
- Microphthalmia transcription factor, a melanocytic nuclear protein critical for the embryonic development and postnatal viability of melanocytes, is a master regulator in modulating extracellular signals. Recently, microphthalmia transcription factor expression was shown to be both a sensitive and specific marker of epithelioid melanoma. We investigated the sensitivity of D5, an anti-microphthalmia transcription factor antibody, for diagnosis of clear cell sarcoma (also known as malignant melanoma of soft parts). Immunoreactivity in a nuclear pattern for D5 was present in 8 of 12 (75%) tumors. D5 staining was strong in three tumors, moderate in two, and weak in three. S-100 protein expression was seen in all 12 cases that had clear cell sarcoma examined. HMB-45 staining was seen in 11 of 12 (92%) tumors. Focal Melan-A positivity was seen in 3 of 7 (43%) tumors. Although D5 was shown in a previous study to be a highly sensitive and specific marker for epithelioid melanomas, the results of this study expand the spectrum of tumors showing immunoreactivity for D5. D5 immunoreactivity in clear cell sarcoma provides further evidence for melanocytic differentiation in this unusual tumor.
- Subjects :
- Adolescent
Adult
Biomarkers, Tumor metabolism
Cell Differentiation
Child
Female
Fluorescent Antibody Technique, Direct
Humans
Male
Melanocytes immunology
Microphthalmia-Associated Transcription Factor
Middle Aged
Neoplasm Proteins metabolism
Sarcoma, Clear Cell pathology
Sensitivity and Specificity
Soft Tissue Neoplasms pathology
DNA-Binding Proteins biosynthesis
Melanocytes metabolism
Sarcoma, Clear Cell metabolism
Soft Tissue Neoplasms metabolism
Transcription Factors biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0893-3952
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
- Publication Type :
- Academic Journal
- Accession number :
- 11211309
- Full Text :
- https://doi.org/10.1038/modpathol.3880249