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p53, but not c-Ki-ras, mutation and down-regulation of p21WAF1/CIP1 and cyclin D1 are associated with malignant transformation in gastric hyperplastic polyps.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2001 Feb; Vol. 115 (2), pp. 224-34. - Publication Year :
- 2001
-
Abstract
- To investigate tumorigenesis in the gastric hyperplastic polyp (HP), we evaluated 19 HPs with and 50 HPs without dysplasia (including carcinoma in situ), as compared with normal mucosa and fundic gland polyps. Helicobacter pylori density was highest in HPs without dysplasia. Apoptotic activity and Ki-67 and p53 expression also were higher in dysplasia in HPs than in normal mucosa, fundic gland polyps, or HPs themselves. The p21WAF1/CIP1 and cyclin D1 levels, in contrast, were highest in HPs. In HPs without dysplasia, size was correlated positively with the degree of stromal inflammation and with p53 and cyclin D1 expression. p53 and c-Ki-ras mutations were detected in 41% (8/19) and 5% (1/19) of dysplasia (including carcinoma in situ) in HPs. Our results demonstrate that the HP enlarges with enhanced cell turnover and overexpression of p53, p21WAF1/CIP1, and cyclin D1, associated with H pylori-related inflammation, and that p53 but not c-Ki-ras mutations may have an important role in dysplastic change in HPs.
- Subjects :
- Adult
Aged
Aged, 80 and over
Apoptosis
Carcinoma in Situ genetics
Carcinoma in Situ pathology
Cell Transformation, Neoplastic
Cyclin-Dependent Kinase Inhibitor p21
DNA, Neoplasm analysis
Down-Regulation
Female
Helicobacter pylori isolation & purification
Humans
Hyperplasia genetics
Hyperplasia metabolism
Hyperplasia pathology
Immunoenzyme Techniques
Ki-67 Antigen metabolism
Male
Middle Aged
Polymerase Chain Reaction
Polyps genetics
Polyps pathology
Proto-Oncogene Proteins p21(ras) metabolism
Stomach Neoplasms genetics
Stomach Neoplasms pathology
Tumor Suppressor Protein p53 metabolism
Carcinoma in Situ metabolism
Cyclin D1 metabolism
Cyclins metabolism
Mutation
Polyps metabolism
Proto-Oncogene Proteins p21(ras) genetics
Stomach Neoplasms metabolism
Tumor Suppressor Protein p53 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9173
- Volume :
- 115
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 11211611
- Full Text :
- https://doi.org/10.1309/VLF5-UCNH-XQM2-X410