[The in vitro metabolism of hainanensine derivative HH07A by rat liver microsomes].

Authors :: Zhang WJ
Zhou TH
Cui YY
Source :: Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 1997; Vol. 32 (2), pp. 116-20.
Publication Year :: 1997
Abstract: The metabolism of hainanensine derivative HH07A has been studied in vitro with rat microsomes. A method of HPLC-DAD was developed for screening the metabolites from the microsomal incubation system. Two metabolites were found according to their UV spectra. One of them was extracted and purified with preparative HPLC and TLC, its chemical structure was identified by UV, IR, MS and NMR.

Subjects :: Animals
Harringtonines chemistry
Harringtonines isolation & purification
In Vitro Techniques
Male
Molecular Structure
Rats
Rats, Wistar
Harringtonines metabolism
Microsomes, Liver metabolism

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