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No association between IL-10 promoter gene polymorphism and heart failure or rejection following cardiac transplantation.
No association between IL-10 promoter gene polymorphism and heart failure or rejection following cardiac transplantation.
- Source :
-
Tissue antigens [Tissue Antigens] 2001 Feb; Vol. 57 (2), pp. 151-3. - Publication Year :
- 2001
-
Abstract
- Expression of interleukin (IL)-10 influences the frequency of rejection events after organ transplantation. Therefore, 70 heart transplant patients were genotyped for three single nucleotide polymorphisms and a microsatellite polymorphism in the promotor region of the IL-10 gene. The promoter region was amplified by polymerase chain reaction and genotyped by a colorometric oligo ligation assay and gene scan analysis, respectively. Patient groups consisted of patients suffering from dilated cardiomyopathy or ischaemic heart disease. Cardiac donors served as control group. No correlation was found between genotypes and heart failure or rejection after heart transplantation. This may indicate that in heart transplantation, the total balance of cytokine production is more important for post-transplant rejection activities than the levels of IL-10 as such.
- Subjects :
- Gene Expression immunology
Graft Rejection immunology
Heart Failure immunology
Heart Failure surgery
Humans
Promoter Regions, Genetic immunology
Graft Rejection genetics
Heart Failure genetics
Heart Transplantation
Interleukin-10 genetics
Polymorphism, Single Nucleotide
Promoter Regions, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0001-2815
- Volume :
- 57
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Tissue antigens
- Publication Type :
- Academic Journal
- Accession number :
- 11260510
- Full Text :
- https://doi.org/10.1034/j.1399-0039.2001.057002151.x