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p53 expression in correlation to clinical outcome in patients with renal cell carcinoma.
- Source :
-
Scandinavian journal of urology and nephrology [Scand J Urol Nephrol] 2001 Feb; Vol. 35 (1), pp. 15-20. - Publication Year :
- 2001
-
Abstract
- Objective: The aim of this study was to evaluate the role of p53 as prognostic factor in renal cell carcinoma (RCC) and its relation to clinicopathological factors.<br />Material and Methods: The nuclear accumulation of p53 protein was determined by immunohistochemical analysis in RCC specimens from 90 patients and was correlated with clinical stage, grade, DNA ploidy, S-phase fraction and cancer-specific survival.<br />Results: p53 overexpression was observed in 17 of 90 (19%) tumours. There was a significant correlation to stage (p = 0.016) and grade (p = 0.020) but not to DNA ploidy or S-phase. Patients with high p53 immunoreactivity had shorter cancer-specific survival (p = 0.003) than those with normal p53 protein expression. This difference was found in papillary and chromophobe tumour types (p < 0.0001) but not in conventional RCC.<br />Conclusions: In patients with RCC, significant correlations between p53 protein expression and tumour stage, grade and survival time were observed. For patients with chromophobe and papillary tumour types, but not in conventional RCC, p53 immunoreactivity gave prognostic information, suggesting that the prognostic differences in p53 immunoreactivity might be due to disparate genetic abnormalities in the different RCC types.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biopsy, Needle
Carcinoma, Renal Cell genetics
Carcinoma, Renal Cell mortality
Carcinoma, Renal Cell pathology
Female
Humans
Immunohistochemistry
Kidney Neoplasms genetics
Kidney Neoplasms mortality
Kidney Neoplasms pathology
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Ploidies
Probability
Prognosis
Proportional Hazards Models
Risk Factors
Sensitivity and Specificity
Statistics, Nonparametric
Survival Rate
Biomarkers, Tumor analysis
Carcinoma, Renal Cell chemistry
Kidney Neoplasms chemistry
Tumor Suppressor Protein p53 analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0036-5599
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of urology and nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 11291681
- Full Text :
- https://doi.org/10.1080/00365590151030705