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Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation.

Authors :
Chandrasekhar SS
Source :
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology [Otol Neurotol] 2001 Jan; Vol. 22 (1), pp. 18-23.
Publication Year :
2001

Abstract

Objective: To discuss the value of intratympanic dexamethasone (IT-DEX) perfusion for sudden sensorineural hearing loss (SSNHL), clinically and in an animal model.<br />Study Design: Retrospective case review of 10 patients with SSNHL treated with IT-DEX. The findings are correlated with this institution's previous findings from a study of IT-DEX in guinea pigs.<br />Setting: Ambulatory tertiary otologic referral center.<br />Patients: Sequential patients with SSNHL who chose IT-DEX treatment.<br />Interventions: Dexamethasone 0.5 mg was injected transtympanically and bathed the round window for 20 minutes. Animal study: 79 ears were randomized into five groups: control, IT-DEX versus intravenous (IV)-DEX, IT-DEX with histamine, IT-DEX with hyaluronic acid, and IT-DEX with dimethylsulfoxide.<br />Main Outcome Measures: Clinical study: postprocedure audiometry. Animal study: perilymph steroid concentration.<br />Results: IT-DEX results in significant hearing improvement and in significantly higher perilymph concentration of steroid than IV-DEX.<br />Conclusions: IT-DEX is an appropriate treatment option for the treatment of SSNHL. Further study of dosages and frequency of administration is warranted.

Details

Language :
English
ISSN :
1531-7129
Volume :
22
Issue :
1
Database :
MEDLINE
Journal :
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Publication Type :
Academic Journal
Accession number :
11314710
Full Text :
https://doi.org/10.1097/00129492-200101000-00005