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Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation.
- Source :
-
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology [Otol Neurotol] 2001 Jan; Vol. 22 (1), pp. 18-23. - Publication Year :
- 2001
-
Abstract
- Objective: To discuss the value of intratympanic dexamethasone (IT-DEX) perfusion for sudden sensorineural hearing loss (SSNHL), clinically and in an animal model.<br />Study Design: Retrospective case review of 10 patients with SSNHL treated with IT-DEX. The findings are correlated with this institution's previous findings from a study of IT-DEX in guinea pigs.<br />Setting: Ambulatory tertiary otologic referral center.<br />Patients: Sequential patients with SSNHL who chose IT-DEX treatment.<br />Interventions: Dexamethasone 0.5 mg was injected transtympanically and bathed the round window for 20 minutes. Animal study: 79 ears were randomized into five groups: control, IT-DEX versus intravenous (IV)-DEX, IT-DEX with histamine, IT-DEX with hyaluronic acid, and IT-DEX with dimethylsulfoxide.<br />Main Outcome Measures: Clinical study: postprocedure audiometry. Animal study: perilymph steroid concentration.<br />Results: IT-DEX results in significant hearing improvement and in significantly higher perilymph concentration of steroid than IV-DEX.<br />Conclusions: IT-DEX is an appropriate treatment option for the treatment of SSNHL. Further study of dosages and frequency of administration is warranted.
- Subjects :
- Administration, Topical
Adolescent
Adult
Aged
Analysis of Variance
Animals
Anti-Inflammatory Agents administration & dosage
Audiometry, Pure-Tone
Dexamethasone administration & dosage
Drug Administration Schedule
Female
Guinea Pigs
Hearing Loss, Sudden physiopathology
Humans
Male
Middle Aged
Random Allocation
Retrospective Studies
Speech Perception physiology
Speech Reception Threshold Test
Treatment Outcome
Anti-Inflammatory Agents therapeutic use
Dexamethasone therapeutic use
Disease Models, Animal
Hearing Loss, Sudden diagnosis
Hearing Loss, Sudden drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1531-7129
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
- Publication Type :
- Academic Journal
- Accession number :
- 11314710
- Full Text :
- https://doi.org/10.1097/00129492-200101000-00005