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Novel non-peptide ligands for the somatostatin sst3 receptor.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Apr 23; Vol. 11 (8), pp. 991-5. - Publication Year :
- 2001
-
Abstract
- A series of imidazole derivatives has been prepared using high throughput parallel synthesis. Several compounds showed high affinity (Ki in 10(-6)-10(-8) M range) and selectivity at recombinant human somatostatin receptor subtype 3 (hsst3).
- Subjects :
- Amides chemical synthesis
Animals
Binding Sites physiology
CHO Cells
Cricetinae
Cyclic AMP analysis
Cyclic AMP biosynthesis
Dose-Response Relationship, Drug
Humans
Imidazoles chemical synthesis
Imidazoles pharmacology
Ligands
Nitrobenzenes chemical synthesis
Protein Binding physiology
Recombinant Proteins antagonists & inhibitors
Amides pharmacology
Colforsin pharmacology
Cyclic AMP agonists
Nitrobenzenes pharmacology
Receptors, Somatostatin antagonists & inhibitors
Somatostatin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 11
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 11327607
- Full Text :
- https://doi.org/10.1016/s0960-894x(01)00107-x