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Genetic alterations in primary mediastinal B-cell lymphoma: an update.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2001 Mar; Vol. 41 (1-2), pp. 47-53. - Publication Year :
- 2001
-
Abstract
- Primary mediastinal B-cell lymphoma (PMBL) is a distinct clinical entity among non-Hodgkin's lymphoma. The malignancy has received little attention from a standpoint of basic research due in part to its rarity. However, based on recent studies consistent trends are beginning to emerge regarding the molecular and chromosomal alterations commonly observed in this disease. By both CGH and AP-PCR, genetic gains involving chromosomes 2, 5, 7, 9p, 12, and Xq are among the most frequently observed events. From a molecular standpoint, alterations in the c-myc, p16(INK4) and p53 genes have been observed in up to 30% of cases. This information along with the well-established histological, immunological, and clinical features should convince the few remaining disbelievers that PMBL is a distinct pathological entity among non-Hodgkin's lymphomas.
- Subjects :
- Chromosome Aberrations diagnosis
Chromosome Disorders
Humans
Lymphoma, B-Cell classification
Lymphoma, B-Cell etiology
Mediastinal Neoplasms classification
Mediastinal Neoplasms etiology
Neoplasm Proteins genetics
Neoplasm Proteins physiology
Lymphoma, B-Cell genetics
Mediastinal Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1042-8194
- Volume :
- 41
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 11342356
- Full Text :
- https://doi.org/10.3109/10428190109057953