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[Treatment of uveitis with immunosuppressives: antimetabolites and alkylating agents].
- Source :
-
Bulletin de la Societe belge d'ophtalmologie [Bull Soc Belge Ophtalmol] 2001 (279), pp. 49-59. - Publication Year :
- 2001
-
Abstract
- Oral corticosteroids remain the main therapeutical choice in patients with uveitis not responding to topical treatment, however their chronic use can be very toxic, especially for bones (osteoporosis or growth retardation). Immunosuppresive agents are used as corticosteroid sparing agents and/or as agents able to control refractory uveitis in sight threatening uveitis. Cyclosporin A is very efficacious but is nephrotoxic, in particular in old people. Methotrexate is well tolerated in young people, is not carcinogenic but not very active. Azathioprine is well tolerated but it's carcinogenic effect and its delayed action are helpful in chronic uveitis of old women. Cyclophosphamide and intravenous steroids are helpful for emergencies. Chlorambucil is toxic and carcinogenic but might lead to an increased rate of remission and might be useful as a short treatment. In any case, a careful and regular follow-up in collaboration with a competent internist is mandatory.
- Subjects :
- Adult
Aged
Azathioprine adverse effects
Azathioprine therapeutic use
Child
Chlorambucil adverse effects
Chlorambucil therapeutic use
Cyclophosphamide therapeutic use
Female
Humans
Methotrexate adverse effects
Methotrexate therapeutic use
Mycophenolic Acid analogs & derivatives
Antimetabolites therapeutic use
Antineoplastic Agents, Alkylating therapeutic use
Immunosuppressive Agents therapeutic use
Uveitis drug therapy
Subjects
Details
- Language :
- French
- ISSN :
- 0081-0746
- Issue :
- 279
- Database :
- MEDLINE
- Journal :
- Bulletin de la Societe belge d'ophtalmologie
- Publication Type :
- Academic Journal
- Accession number :
- 11344715