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Selective delta opioid receptor agonists for inflammatory and neuropathic pain.
- Source :
-
Farmaco (Societa chimica italiana : 1989) [Farmaco] 2001 Jan-Feb; Vol. 56 (1-2), pp. 117-9. - Publication Year :
- 2001
-
Abstract
- In the last decade a number of selective and potent non-peptidic agents became available to explore the usefulness of the delta-opioid receptor in modulation of pain of different origins. As a continuing effort in this field, potent and selective delta-opioid agonists based on the pyrrolomorphinan framework have been designed, synthesised and characterised biologically in our laboratories. In animal models, a selected compound of interest, SB 235863, has proved the concept that selective delta-opioid agonists may have great potential as pain relief agents in inflammatory and neuropathic pain conditions. Importantly, such a compound was free of the unwanted side effects usually associated with narcotic analgesics such as morphine.
Details
- Language :
- English
- ISSN :
- 0014-827X
- Volume :
- 56
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Farmaco (Societa chimica italiana : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 11347951
- Full Text :
- https://doi.org/10.1016/s0014-827x(01)01020-5