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Sex dependent toxicity of four chemicals.
- Source :
-
Research communications in chemical pathology and pharmacology [Res Commun Chem Pathol Pharmacol] 1975 Mar; Vol. 10 (3), pp. 577-80. - Publication Year :
- 1975
-
Abstract
- Toxicity investigations were conducted with 4 chemicals: hydrazine, 1,2-dimethylhydrazine di HCl, phenylhydrazine HCl and Beta-N-(gamma-L(+)-glutamyl)-4-hydroxymethylphenylhydrazine in Swiss mice. Hydrazine and phenylhydrazine HCl were administered daily in drinking water, the former at 0.01% and the latter at 0.001% concentrations. The 1,2-dimethylhydrazine di HCl and Beta-N-(gamma-L(+)-glutamyl)-4-hydroxymethylphenylhydrazine were given as a single subcutaneous injection at 45 mug and 100 mug/gr. body weight basis, respectively. The findings clearly showed that all four chemicals exerted a stronger toxic effect in male than in female mice. It is, therefore, recommended in similar situations to use different doses of chemicals for each sex in the long-term tumorigenesis studies.
Details
- Language :
- English
- ISSN :
- 0034-5164
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Research communications in chemical pathology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1135520