Induction of alpha1-acid glycoprotein mRNA by cytokines and differentiation in human colon carcinoma cell.

Authors :: Lee Y
Lim JW
Kim YM
Lee IH
Choi YC
Park KC
Source :: Molecules and cells [Mol Cells] 2001 Apr 30; Vol. 11 (2), pp. 164-9.
Publication Year :: 2001
Abstract: The mRNA for the alpha1-acid glycoprotein (AAG) was expressed not only in hepatoma cells, but also in non-hepatic cancer cells. The expression of the AAG mRNA in HT-29 human colon carcinoma cells is induced by cytokines, IL-6, IL-1, and TNF-alpha, in a manner characteristic of the acute phase response, and the expression of AAG mRNA was up-regulated in differentiated HT-29 cells.

Subjects :: Cell Differentiation
Colonic Neoplasms pathology
Culture Media, Serum-Free
HT29 Cells
HeLa Cells
Humans
Interleukin-1 pharmacology
Interleukin-6 pharmacology
Orosomucoid biosynthesis
RNA, Messenger genetics
RNA, Messenger metabolism
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha pharmacology
Colonic Neoplasms genetics
Gene Expression Regulation, Neoplastic
Orosomucoid genetics

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