Protection from superoxide damage associated with an increased level of the YggX protein in Salmonella enterica.

Authors :: Gralnick J
Downs D
Source :: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2001 Jul 03; Vol. 98 (14), pp. 8030-5. Date of Electronic Publication: 2001 Jun 19.
Publication Year :: 2001
Abstract: The deleterious effect of superoxide radicals on cell growth and survival is predominantly caused by rapid oxidation of labile [Fe-S] clusters in proteins. Oxidation of these clusters releases Fe(II) ions, which participate in Fenton chemistry that damages DNA. Here it is shown that elevated levels of the YggX protein increase the resistance of Salmonella enterica to superoxide stress, reverse enzymatic defects attributed to oxidized [Fe-S] clusters, and decrease the spontaneous mutation frequency. The data are consistent with a model in which YggX protects protein [Fe-S] clusters from oxidation.

Subjects :: Amino Acid Sequence
Bacterial Proteins genetics
Molecular Sequence Data
Mutation
Oxidative Stress
Salmonella enterica genetics
Sequence Alignment
Bacterial Proteins metabolism
Salmonella enterica metabolism
Superoxides metabolism

Language :: English
ISSN :: 0027-8424
Volume :: 98
Issue :: 14
Database :: MEDLINE
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 11416172
Full Text :: https://doi.org/10.1073/pnas.151243198

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