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Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB.
- Source :
-
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2001 Jul; Vol. 15 (9), pp. 1622-4. - Publication Year :
- 2001
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Celecoxib
Cyclooxygenase 2
Dinoprostone metabolism
Disease Models, Animal
Inflammation chemically induced
Inflammation drug therapy
Interleukin-1 metabolism
Isoenzymes genetics
Isoenzymes metabolism
Male
Prostaglandin-Endoperoxide Synthases genetics
Prostaglandin-Endoperoxide Synthases metabolism
Pyrazoles
Rats
Rats, Sprague-Dawley
Sulfonamides administration & dosage
Sulfonamides pharmacology
Transcription, Genetic drug effects
Tumor Necrosis Factor-alpha metabolism
Zymosan
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
NF-kappa B metabolism
Sulfonamides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0892-6638
- Volume :
- 15
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 11427506
- Full Text :
- https://doi.org/10.1096/fj.00-0716fje