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Reduced number of CD1a+ cells in cutaneous B-cell lymphoma.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2001 Jul; Vol. 116 (1), pp. 72-8. - Publication Year :
- 2001
-
Abstract
- Cutaneous B-cell lymphoma is difficult to distinguish from pseudolymphoma. The histologic pattern and monoclonal restriction (immunohistochemical analysis and molecular biology) are the criteria used for differentiating these entities. CD1a+ dendritic cells have been observed in the infiltrates of T-cell lymphoma, but the presence of these CD1a+ cells has not been compared in B-cell lymphoma and pseudolymphoma. We studied the presence of CD1a+ cells on frozen sections of 23 B-cell lymphomas, 13 pseudolymphomas, and 17 T-cell lymphomas by immunohistochemical analysis. We found abundant CD1a+ dendritic cells in only 1 (4%) of 23 B-cell lymphomas, whereas in 8 (62%) of 13 pseudolymphomas and 17 (100%) of 17 T-cell lymphomas, strong CD1a staining was present. Our study demonstrates a distinct pattern of CD1a staining in the infiltrates of B-cell lymphoma and pseudolymphoma that may be of value in the differential diagnosis of these skin disorders.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antigen-Presenting Cells metabolism
Antigen-Presenting Cells pathology
Cell Count
Female
Humans
Lymphoma, B-Cell pathology
Lymphoma, T-Cell metabolism
Lymphoma, T-Cell pathology
Male
Middle Aged
Pseudolymphoma metabolism
Pseudolymphoma pathology
Antigens, CD1 metabolism
Lymphoma, B-Cell metabolism
Skin Neoplasms metabolism
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9173
- Volume :
- 116
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 11447755
- Full Text :
- https://doi.org/10.1309/G828-D7YC-Y98R-QRR9