The 2-deoxyribonolactone lesion produced in DNA by neocarzinostatin and other damaging agents forms cross-links with the base-excision repair enzyme endonuclease III.

Authors :: Hashimoto M
Greenberg MM
Kow YW
Hwang JT
Cunningham RP
Source :: Journal of the American Chemical Society [J Am Chem Soc] 2001 Apr 04; Vol. 123 (13), pp. 3161-2.
Publication Year :: 2001

Subjects :: Antibiotics, Antineoplastic toxicity
Cross-Linking Reagents toxicity
DNA metabolism
DNA Damage
DNA Repair
Deoxyribonuclease (Pyrimidine Dimer)
Endodeoxyribonucleases metabolism
Escherichia coli Proteins
Sugar Acids metabolism
Zinostatin toxicity

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