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Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum.
- Source :
-
Regulatory peptides [Regul Pept] 2001 Sep 15; Vol. 101 (1-3), pp. 87-91. - Publication Year :
- 2001
-
Abstract
- Objective: The purpose of this study was to investigate the effects of progesterone and the most commonly prescribed synthetic progestogen, norethisterone, on regional immune-like reactivity of neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA) and neurotensin (NT) in brains of female ovariectomized estradiol-substituted rats.<br />Results: Norethisterone+estradiol-treated rats had 44% lower SP levels compared with estradiol-only-treated in frontal cortex and 20% lower NKA levels in comparison with progesterone+estradiol-treated in frontal cortex. Progesterone+estradiol-treated rats had 66% lower SP levels in striatum in comparison with both estradiol-only-treated and norethisterone+estradiol-treated. No significant results were found for NPY and NT.<br />Conclusion: Progesterone and the synthetic progestogen, norethisterone, have different effects on SP- and NKA-like immunoreactivity in rat cortex and striatum. The effects of NET on SP- and NKA-like immunoreactivity in frontal cortex may contribute to the mood effects ascribed to this progestogen in clinical usage.
- Subjects :
- Animals
Delayed-Action Preparations
Estradiol pharmacology
Female
Hippocampus metabolism
Neurokinin A immunology
Neurokinin A metabolism
Neuropeptide Y immunology
Neuropeptide Y metabolism
Neurotensin immunology
Neurotensin metabolism
Norethindrone administration & dosage
Ovariectomy
Progesterone administration & dosage
Progesterone Congeners administration & dosage
Radioimmunoassay
Rats
Substance P immunology
Substance P metabolism
Tachykinins immunology
Cerebral Cortex metabolism
Neostriatum metabolism
Norethindrone pharmacology
Progesterone pharmacology
Progesterone Congeners pharmacology
Tachykinins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0167-0115
- Volume :
- 101
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Regulatory peptides
- Publication Type :
- Academic Journal
- Accession number :
- 11495683
- Full Text :
- https://doi.org/10.1016/s0167-0115(01)00265-8