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Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum.

Authors :
Rugarn O
Hammar M
Theodorsson E
Source :
Regulatory peptides [Regul Pept] 2001 Sep 15; Vol. 101 (1-3), pp. 87-91.
Publication Year :
2001

Abstract

Objective: The purpose of this study was to investigate the effects of progesterone and the most commonly prescribed synthetic progestogen, norethisterone, on regional immune-like reactivity of neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA) and neurotensin (NT) in brains of female ovariectomized estradiol-substituted rats.<br />Results: Norethisterone+estradiol-treated rats had 44% lower SP levels compared with estradiol-only-treated in frontal cortex and 20% lower NKA levels in comparison with progesterone+estradiol-treated in frontal cortex. Progesterone+estradiol-treated rats had 66% lower SP levels in striatum in comparison with both estradiol-only-treated and norethisterone+estradiol-treated. No significant results were found for NPY and NT.<br />Conclusion: Progesterone and the synthetic progestogen, norethisterone, have different effects on SP- and NKA-like immunoreactivity in rat cortex and striatum. The effects of NET on SP- and NKA-like immunoreactivity in frontal cortex may contribute to the mood effects ascribed to this progestogen in clinical usage.

Details

Language :
English
ISSN :
0167-0115
Volume :
101
Issue :
1-3
Database :
MEDLINE
Journal :
Regulatory peptides
Publication Type :
Academic Journal
Accession number :
11495683
Full Text :
https://doi.org/10.1016/s0167-0115(01)00265-8