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Effect of additional chromosomal abnormalities in acute promyelocytic leukemia treated with all-trans-retinoic acid: a report of 17 patients.
- Source :
-
International journal of hematology [Int J Hematol] 2001 Jun; Vol. 73 (4), pp. 496-501. - Publication Year :
- 2001
-
Abstract
- Seventeen cases of acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and combination chemotherapy at Tokyo Metropolitan Komagome Hospital between 1992 and 1999 were reviewed, and divided into 2 karyotype-based cytogenetic groups. One group comprised 7 patients with either the typical t(15;17) alone or a normal karyotype, and the other group comprised 10 patients with additional karyotypic abnormalities. No patient had received prior chemotherapy or irradiation, and no cases were complicated by a history of myelodysplastic syndrome before the diagnosis of APL. There were no significant differences in clinical characteristics at disease presentation. Complete remission was achieved in all 17 patients and karyotypes of bone marrow cells normalized in all cases. No differences were found in relapse rate, overall survival, or disease-free survival between the 2 groups. The analysis did not reveal any significant effect of additional chromosomal abnormalities on the prognosis of APL patients undergoing treatment with ATRA. However, a small number of patients were assessed in this study, and further cumulative studies are needed.
- Subjects :
- Adolescent
Adult
Aged
Cytogenetic Analysis
Female
Humans
Leukemia, Promyelocytic, Acute diagnosis
Leukemia, Promyelocytic, Acute genetics
Male
Middle Aged
Prognosis
Retrospective Studies
Treatment Outcome
Chromosome Aberrations
Leukemia, Promyelocytic, Acute drug therapy
Tretinoin administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0925-5710
- Volume :
- 73
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 11503965
- Full Text :
- https://doi.org/10.1007/BF02994013