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Low-dosage esterified estrogens opposed by progestin at 6-month intervals.
- Source :
-
Obstetrics and gynecology [Obstet Gynecol] 2001 Aug; Vol. 98 (2), pp. 205-11. - Publication Year :
- 2001
-
Abstract
- Objective: To estimate incidence of endometrial hyperplasia, vaginal bleeding, and menopausal symptoms in women who changed from standard monthly cyclic hormone replacement therapy (HRT) to half-strength estrogen opposed by medroxyprogesterone acetate (MPA) at 6-month intervals.<br />Methods: We identified 138 women aged 55-75 years who had regularly used HRT at a standard dosage (equivalent to 0.625 mg conjugated estrogen) opposed by cyclic monthly MPA. Each subject's HRT regimen was changed to 0.3 mg/day esterified estrogens (Estratab; Solvay Pharmaceuticals, Marietta, GA) combined with 14-day courses of MPA, 10 mg/day, every 6 months. Endometrial biopsy was repeated after 1 year of the new regimen. Any vaginal bleeding was reported in each patient's daily diary. Menopause symptoms were evaluated using the Greene Menopause Symptom Index.<br />Results: Among 125 women who had biopsy after 1 year of the new regimen, endometrial hyperplasia was found in two (1.6%, 95% confidence interval 0.3%, 6.2%). Of the 125 women, 44% had scheduled bleeding, and 9.4% had unscheduled bleeding. Relative to baseline vasomotor score (range 0-6), an increase of at least 2 U was reported by 20% of subjects at 6 months and by 17% of subjects at 12 months.<br />Conclusion: Most women aged at least 55 years can safely switch their HRT regimen from standard dosage HRT to low-dosage estrogen opposed by MPA at 6-month intervals. Moreover, this new HRT regimen causes little vaginal bleeding while maintaining adequate control of menopausal symptoms.
- Subjects :
- Aged
Biopsy, Needle
Endometrium drug effects
Endometrium pathology
Estrogens adverse effects
Female
Humans
Medroxyprogesterone Acetate adverse effects
Middle Aged
Progesterone Congeners adverse effects
Estradiol Congeners
Estrogen Replacement Therapy
Estrogens administration & dosage
Medroxyprogesterone Acetate administration & dosage
Progesterone Congeners administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0029-7844
- Volume :
- 98
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 11506834
- Full Text :
- https://doi.org/10.1016/s0029-7844(01)01419-3