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Effect of 9-hydroxylation on benzomorphan antagonist activity.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 1975 Jun; Vol. 18 (6), pp. 619-21. - Publication Year :
- 1975
-
Abstract
- In a benzomorphan bearing an antagonist side chain, introduction on the methano bridge of a hydroxyl oriented away from nitrogen has little effect on antagonist activity whereas a hydroxyl oriented toward nitrogen enhances this activity. Hydroxylation tends to decrease analgesic activity.
- Subjects :
- Animals
Benzomorphans analogs & derivatives
Benzomorphans pharmacology
Hydroxylation
Meperidine antagonists & inhibitors
Molecular Conformation
Narcotic Antagonists pharmacology
Phenazocine antagonists & inhibitors
Rats
Structure-Activity Relationship
Benzomorphans chemical synthesis
Morphinans chemical synthesis
Narcotic Antagonists chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 1151978
- Full Text :
- https://doi.org/10.1021/jm00240a019