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Ventilatory patterns following burn injury and effect of sulfamylon.
- Source :
-
The Journal of trauma [J Trauma] 1975 Aug; Vol. 15 (8), pp. 650-6. - Publication Year :
- 1975
-
Abstract
- Seven burn patients treated with silver nitrate dressings were studied during the first 10 days after injury. Minute ventilation, oxygen consumption, and ventilatory equivalent were measured. Minute ventilation was increased two- to threefold, as was oxygen consumption. Ventilatory equivalent was only slightly increased. THree patients were initially treated with silver nitrate, and then, when clinically stable, were switched to Sulfamylon. They showed a 50% rise in ventilation, tidal volume, ventilatory equivalent, and a slight increase in respiratory rate and VD/VT. In addition, their PO2 increased and base excess fell. Five normal subjects were then given Diamox, and their minute ventilation, O2 consumption, and ventilatory equivalent were measured at rest, with a standard exercise, and with an added dead space. Diamox produced only a 25% increase in minute ventilation and ventilatory equivalent. The results suggest that, although some of the increased ventilation of Sulfamylon is due to carbonic anhydrase inhibition, another factor, such as pain casued by the topical agent, also plays a role.
- Subjects :
- Acetazolamide pharmacology
Acetazolamide therapeutic use
Acid-Base Equilibrium drug effects
Adolescent
Adult
Bandages
Burns drug therapy
Burns physiopathology
Carbon Dioxide biosynthesis
Carbonic Anhydrase Inhibitors pharmacology
Humans
Male
Oxygen blood
Oxygen Consumption drug effects
Physical Exertion
Respiratory Dead Space drug effects
Silver Nitrate pharmacology
Silver Nitrate therapeutic use
Tidal Volume
Vital Capacity drug effects
Burns complications
Mafenide therapeutic use
Respiration drug effects
Sulfonamides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0022-5282
- Volume :
- 15
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of trauma
- Publication Type :
- Academic Journal
- Accession number :
- 1152087
- Full Text :
- https://doi.org/10.1097/00005373-197508000-00005