HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum.

Authors :: Kim HJ
Woo ER
Shin CG
Hwang DJ
Park H
Lee YS
Source :: Archives of pharmacal research [Arch Pharm Res] 2001 Aug; Vol. 24 (4), pp. 286-91.
Publication Year :: 2001
Abstract: Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Compounds 1 and 2 showed potent inhibitory activities against HIV-1 integrase with IC50 values of 7.8 +/- 3.6 and 13.7 +/- 6.0 microM, respectively.

Subjects :: Guaiacol pharmacology
Humans
Magnetic Resonance Spectroscopy
Oligonucleotides pharmacology
Plant Extracts analysis
Plant Extracts pharmacology
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Disaccharides pharmacology
Guaiacol analogs & derivatives
HIV Integrase Inhibitors pharmacology
HIV-1 enzymology
Plants, Medicinal chemistry

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