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Effect of saponin on mortality and histopathological changes in mice.

Authors :
Diwan FH
Abdel-Hassan IA
Mohammed ST
Source :
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit [East Mediterr Health J] 2000 Mar-May; Vol. 6 (2-3), pp. 345-51.
Publication Year :
2000

Abstract

We evaluated the acute toxicity and histopathological effects of saponin (extracted from the plant Citrullus colocynthis) on mice in order to assess its safety. The median lethal dose (LD50) of the saponin was 200 mg/kg. The histological changes were confined to the small intestine, liver and kidney, whereas the stomach, large intestine and heart appeared normal. The changes in the small intestine included haemorrhage and erosion of the mucosa. In addition, hepatorenal damage resulted from necrosis of liver cells and renal tubules.

Details

Language :
English
ISSN :
1020-3397
Volume :
6
Issue :
2-3
Database :
MEDLINE
Journal :
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
Publication Type :
Academic Journal
Accession number :
11556022