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Effect of saponin on mortality and histopathological changes in mice.
- Source :
-
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit [East Mediterr Health J] 2000 Mar-May; Vol. 6 (2-3), pp. 345-51. - Publication Year :
- 2000
-
Abstract
- We evaluated the acute toxicity and histopathological effects of saponin (extracted from the plant Citrullus colocynthis) on mice in order to assess its safety. The median lethal dose (LD50) of the saponin was 200 mg/kg. The histological changes were confined to the small intestine, liver and kidney, whereas the stomach, large intestine and heart appeared normal. The changes in the small intestine included haemorrhage and erosion of the mucosa. In addition, hepatorenal damage resulted from necrosis of liver cells and renal tubules.
- Subjects :
- Acute Disease
Animals
Anorexia chemically induced
Anorexia pathology
Blepharoptosis chemically induced
Blepharoptosis pathology
Cause of Death
Diarrhea chemically induced
Diarrhea pathology
Drug Evaluation, Preclinical
Female
Heart Failure chemically induced
Heart Failure pathology
Hemorrhage chemically induced
Hemorrhage pathology
Herbal Medicine
Hypoglycemia chemically induced
Hypoglycemia pathology
Intestine, Small drug effects
Intestine, Small pathology
Iraq
Kidney drug effects
Kidney pathology
Lethal Dose 50
Liver drug effects
Liver pathology
Male
Mice
Mice, Inbred BALB C
Necrosis
Sleep Stages drug effects
Models, Animal
Mortality
Saponins toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1020-3397
- Volume :
- 6
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
- Publication Type :
- Academic Journal
- Accession number :
- 11556022