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Activation and inhibition of succinate-dependent Ca2+ transport in liver mitochondria during adaptation.
- Source :
-
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2001 Jul; Vol. 66 (7), pp. 795-802. - Publication Year :
- 2001
-
Abstract
- Succinate-dependent Ca2+ accumulation was investigated in rat liver mitochondria and in operation biopsies of patients under states either with prevalence of adrenergic influences (administration of activating doses of adrenaline, acute phase of immobilization stress, initial period after allogenic transplantation, and acute phase of myocardial infarction) or with prevalence of the reciprocal mediator acetylcholine (late period after transplantation, chronic ulcer disease of stomach and duodenum). Adrenaline prevalence leads to increase of succinate-dependent ATP synthesis and Ca2+ accumulation, which is due to known activation of succinate oxidation. However, together with activation, inhibition of these processes was revealed. The inhibition phase prevails under chronic pathology. Therefore, reciprocal regulation of succinate oxidation and succinate-dependent Ca2+ transport in mitochondria occurs in the body in the course of adaptation. The reciprocal regulation of mitochondrial processes is considered as a mechanism of reciprocal regulation of physiological functions.
- Subjects :
- Acute Disease
Adaptation, Physiological
Adenosine Triphosphate agonists
Animals
Calcium agonists
Duodenal Ulcer metabolism
Epinephrine pharmacology
Humans
Male
Mitochondria, Liver drug effects
Myocardial Infarction metabolism
Rats
Rats, Wistar
Succinic Acid agonists
Transplantation, Homologous physiology
Adenosine Triphosphate biosynthesis
Calcium metabolism
Epinephrine metabolism
Mitochondria, Liver metabolism
Stress, Physiological metabolism
Succinic Acid metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-2979
- Volume :
- 66
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Biochemistry. Biokhimiia
- Publication Type :
- Academic Journal
- Accession number :
- 11563961
- Full Text :
- https://doi.org/10.1023/a:1010272914835