Back to Search
Start Over
Asymmetric inheritance of radial glial fibers by cortical neurons.
- Source :
-
Neuron [Neuron] 2001 Sep 13; Vol. 31 (5), pp. 727-41. - Publication Year :
- 2001
-
Abstract
- Recent studies demonstrated the neuronogenic role of radial glial cells (RGCs) in the rodent. To reveal the fate of radial glial processes, we intensively monitored divisions of RGCs in DiI-labeled slices from the embryonic day 14 mouse cortex. During RGC division, each pia-connected fiber becomes thin but is neither lost nor divided; it is inherited asymmetrically by one daughter cell. In divisions that produce a neuron and a progenitor, the neuron inherits the pial fiber, also grows a thick ventricular process for several hours, and is therefore indistinguishable from the progenitor RGC. The ventricular process in the radial glial-like neuron ("radial neuron") then collapses, leading to ascent of the neuron by using the "recycled" radial fiber.
- Subjects :
- Aging physiology
Animals
Body Patterning physiology
Cell Compartmentation physiology
Cell Lineage physiology
Cell Size physiology
Cerebral Cortex cytology
Cerebral Cortex metabolism
Fetus
Immunohistochemistry
Mice
Mice, Inbred ICR
Nerve Tissue Proteins metabolism
Neurites metabolism
Neurites ultrastructure
Neuroglia metabolism
Neurons metabolism
Organ Culture Techniques
Stem Cells metabolism
Cell Differentiation physiology
Cell Division physiology
Cell Movement physiology
Cerebral Cortex embryology
Neuroglia cytology
Neurons cytology
Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 0896-6273
- Volume :
- 31
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 11567613
- Full Text :
- https://doi.org/10.1016/s0896-6273(01)00420-2