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Synthesis and antimycobacterial activity of 5-aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4, 5-dihydro-1H-pyrazole derivatives.
- Source :
-
Farmaco (Societa chimica italiana : 1989) [Farmaco] 2001 Aug; Vol. 56 (8), pp. 593-9. - Publication Year :
- 2001
-
Abstract
- 5-Aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole derivatives were synthesized and tested for their in vitro antimycobacterial activity. The compounds showed an interesting activity against a strain of Mycobacterium tuberculosis and a human strain of M. tuberculosis H4.
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Antitubercular Agents chemistry
Antitubercular Agents pharmacology
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis drug effects
Mycobacterium tuberculosis isolation & purification
Pyrazoles chemistry
Pyrazoles pharmacology
Structure-Activity Relationship
Anti-Bacterial Agents chemical synthesis
Antitubercular Agents chemical synthesis
Pyrazoles chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0014-827X
- Volume :
- 56
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Farmaco (Societa chimica italiana : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 11601645