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Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.
- Source :
-
Journal of natural products [J Nat Prod] 2001 Oct; Vol. 64 (10), pp. 1278-81. - Publication Year :
- 2001
-
Abstract
- A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2), anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5-8) were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes. Moronic acid (2) showed significant anti-HIV activity (EC(50) <0.1 microg/mL, TI >186) and was modified to develop more potent anti-AIDS agents.
- Subjects :
- Anti-HIV Agents chemistry
Anti-HIV Agents pharmacology
Brazil
Cells, Cultured drug effects
Drug Evaluation, Preclinical
Enzyme-Linked Immunosorbent Assay
HIV-1 drug effects
Humans
Inhibitory Concentration 50
Lymphocytes drug effects
Lymphocytes virology
Magnetic Resonance Spectroscopy
Molecular Structure
Plants, Medicinal chemistry
Structure-Activity Relationship
Triterpenes chemistry
Triterpenes pharmacology
Zidovudine pharmacology
Anti-HIV Agents isolation & purification
Myrtaceae chemistry
Oleanolic Acid analogs & derivatives
Oleanolic Acid chemistry
Oleanolic Acid pharmacology
Propolis chemistry
Triterpenes isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 64
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 11678650
- Full Text :
- https://doi.org/10.1021/np010211x