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Collagenous gastritis: a report of six cases.

Authors :
Lagorce-Pages C
Fabiani B
Bouvier R
Scoazec JY
Durand L
Flejou JF
Source :
The American journal of surgical pathology [Am J Surg Pathol] 2001 Sep; Vol. 25 (9), pp. 1174-9.
Publication Year :
2001

Abstract

Collagenous gastritis is an exceptional entity with eight cases documented to date characterized by the presence of a thick subepithelial collagen band associated with an inflammatory infiltrate of the gastric mucosa. The aim of our study was to describe the clinical and histologic characteristics of six new cases of collagenous gastritis. All cases showed a subepithelial collagen band that averaged 30 microm but often measured up to 120 microm. This finding was almost always accompanied by mixed chronic inflammation in the lamina propria and by surface epithelial damage of varying severity. Our study seems to delineate two subsets in patients with collagenous gastritis: 1) collagenous gastritis occurring in children and young adults presenting with severe anemia, a nodular pattern on endoscopy, and a disease limited to the gastric mucosa without evidence of colonic involvement, and 2) collagenous gastritis associated with collagenous colitis occurring in adult patients presenting with chronic watery diarrhea. These findings highlight the fact that subepithelial collagen deposition may be a generalized disease affecting the entire gastrointestinal tract.

Details

Language :
English
ISSN :
0147-5185
Volume :
25
Issue :
9
Database :
MEDLINE
Journal :
The American journal of surgical pathology
Publication Type :
Academic Journal
Accession number :
11688577
Full Text :
https://doi.org/10.1097/00000478-200109000-00008