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Rearrangements of bcl-1, bcl-2, bcl-6, and c-myc in diffuse large B-cell lymphomas.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2001 Sep-Oct; Vol. 42 (5), pp. 1099-106. - Publication Year :
- 2001
-
Abstract
- Diffuse large B-cell lymphoma (DLBL) is characterized by a marked degree of morphologic and clinical heterogeneity. We studied 137 patients with de novo DLBL for rearrangements of the bcl-1, bcl-2, bcl-6 and c-myc oncogenes by Southern blot analysis. Structural alterations of bcl-1, bcl-2, bcl-6, and c-myc were detected in 21 of 137 (15.3%), 8 of 137 (5.8%), 22 of 137 (16.1%), 14 of 137 (10.2%) patients, respectively. Two cases showed a combination of bcl-1 and bcl-6 rearrangements. Chromosomal analysis was performed in 31 cases of the 137 DLBL. 27 of these showed karyotypic abnormalities, and two had translocations 3q27 involving bcl-6. However, one of two cases had no rearrangement of bcl-6. Patients with rearranged bcl-6 and c-myc tended to have poorer survival than patients with germ-line. Furthermore, bcl-1 and bcl-2 rearrangements tended to have a better outcome, although the above differences were not statistically significant. Rearrangements of the bcl-1, 2, 6, and c-myc gene correlated with the clinical outcome in DLBL and may thus serve as prognostic markers in patients with this form of malignant lymphoma. However, other genetic factors are probably involved in determining prognosis.
- Subjects :
- Adolescent
Adult
Aged
Blotting, Southern
Child
Cytogenetic Analysis
DNA-Binding Proteins genetics
Genes, bcl-1 genetics
Genes, bcl-2 genetics
Genes, myc genetics
Humans
Lymphoma, B-Cell diagnosis
Lymphoma, B-Cell genetics
Lymphoma, B-Cell mortality
Lymphoma, Large B-Cell, Diffuse diagnosis
Lymphoma, Large B-Cell, Diffuse mortality
Middle Aged
Prognosis
Proto-Oncogene Proteins genetics
Proto-Oncogene Proteins c-bcl-6
Survival Analysis
Transcription Factors genetics
Translocation, Genetic
Gene Rearrangement
Lymphoma, Large B-Cell, Diffuse genetics
Proto-Oncogenes genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1042-8194
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 11697627
- Full Text :
- https://doi.org/10.3109/10428190109097730