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[New therapies for the treatment of age-related macular degeneration].
- Source :
-
Journal de la Societe de biologie [J Soc Biol] 2001; Vol. 195 (2), pp. 115-8. - Publication Year :
- 2001
-
Abstract
- Age-related macular degeneration has a natural progression from the precursors (the drusen) towards atrophic or neovascular complications. Choroidal neovascularization is undoubtedly the aspect of the disease that benefits most from new therapeutical approaches. Destructive photocoagulation based on fluorescein angiography has demonstrated since 20 years its efficiency on choroidal neovascularization. The same approach based on indocyanine green (ICG) angiography would increase the number of patients available to therapy. Very recently photodynamic therapy has demonstrated its efficiency to stabilize visual acuity at least at two years in patients with choroidal new vessels predominantly well defined. Other treatment developments are considered, such as refinement of photocoagulation techniques or of surgery. Until now, none has demonstrated its efficiency although they raise justified hopes. The future approaches rely upon the progress of the research both in physiopathology of the disease and on the angiogenic process requiring a constant interaction with all thematics of research. Finally, palliative treatments will be required before heading up to a preventive treatment.
- Subjects :
- Aged
Cell Transplantation
Choroidal Neovascularization diagnosis
Choroidal Neovascularization drug therapy
Choroidal Neovascularization prevention & control
Choroidal Neovascularization surgery
Choroidal Neovascularization therapy
Disease Progression
Fluorescein Angiography
Forecasting
Humans
Indocyanine Green
Laser Coagulation
Light Coagulation
Macular Degeneration drug therapy
Macular Degeneration etiology
Macular Degeneration pathology
Macular Degeneration surgery
Palliative Care
Photochemotherapy
Pigment Epithelium of Eye cytology
Pigment Epithelium of Eye transplantation
Porphyrins therapeutic use
Retinal Drusen pathology
Retinal Drusen therapy
Verteporfin
Visual Acuity
Macular Degeneration therapy
Subjects
Details
- Language :
- French
- ISSN :
- 1295-0661
- Volume :
- 195
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal de la Societe de biologie
- Publication Type :
- Academic Journal
- Accession number :
- 11723822