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Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression.
- Source :
-
The American journal of psychiatry [Am J Psychiatry] 2001 Dec; Vol. 158 (12), pp. 2074-6. - Publication Year :
- 2001
-
Abstract
- Objective: Depression has been associated with increased platelet activation. Variations in the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism may influence the degree of activation. The authors examined the association among depression, platelet activation, and 5-HTTLPR genotype.<br />Method: Elderly subjects with (N=61) and without (N=12) major depression were assessed for cognitive impairment, cardiovascular disease, and two indices of platelet activation. The depressed subjects were genotyped for the 5-HTTLPR polymorphism.<br />Results: The depressed subjects were older, were more cognitively impaired, and had higher platelet factor 4 and beta-thromboglobulin levels; cardiovascular disease was minimal in both groups. In the depressed group, subjects with the 5-HTTLPR l/l genotype had significantly higher platelet factor 4 and beta-thromboglobulin levels.<br />Conclusions: Platelet activation is increased in elderly depressed patients, especially those with the 5-HTTLPR l/l genotype. This finding suggests how genetic differences may influence cardiovascular mortality in depressed patients with ischemic heart disease.
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease blood
Alzheimer Disease genetics
Coronary Thrombosis blood
Coronary Thrombosis genetics
Depressive Disorder, Major blood
Female
Humans
Male
Mental Status Schedule
Platelet Factor 4 metabolism
Risk Factors
Serotonin Plasma Membrane Transport Proteins
beta-Thromboglobulin metabolism
Carrier Proteins genetics
Depressive Disorder, Major genetics
Membrane Glycoproteins genetics
Membrane Transport Proteins
Nerve Tissue Proteins
Platelet Activation genetics
Polymorphism, Genetic genetics
Promoter Regions, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0002-953X
- Volume :
- 158
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The American journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 11729031
- Full Text :
- https://doi.org/10.1176/appi.ajp.158.12.2074