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Aquaporin in Candida: characterization of a functional water channel protein.
- Source :
-
Yeast (Chichester, England) [Yeast] 2001 Nov; Vol. 18 (15), pp. 1391-6. - Publication Year :
- 2001
-
Abstract
- The Candida albicans genome database contains one ORF with homology to aquaporins, AQY1. Xenopus oocytes injected with cRNA encoding C. albicans Aqy1p displayed a coefficient of water permeability (P(f)) that was equivalent to the P(f) for oocytes injected with the cRNA of S. cerevisiae Aqy1p. In addition, as seen in Saccharomyces for Aqy1p and Aqy2p, deletion of AQY1 in C. albicans resulted in cells that were less sensitive than wild-type to osmotic shock. In Saccharomyces, aquaporin null cells also have a cell surface that is more hydrophobic. However, unlike Saccharomyces, there was no effect on the cell surface hydrophobicity, flocculation or cell aggregation in aqy1 null C. albicans cells. Perhaps as a result, there was no difference between the virulence of C. albicans wild-type and aqy1 null strains in a murine model for systemic candidiasis.<br /> (Copyright 2001 John Wiley & Sons, Ltd.)
- Subjects :
- Amino Acid Sequence
Animals
Aquaporin 1
Aquaporins physiology
Biological Assay
Candida albicans metabolism
Candida albicans pathogenicity
Candidiasis microbiology
Disease Models, Animal
Female
Male
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Osmotic Pressure
Sequence Alignment
Sequence Homology, Amino Acid
Surface Properties
Virulence
Aquaporins genetics
Candida albicans genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0749-503X
- Volume :
- 18
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Yeast (Chichester, England)
- Publication Type :
- Academic Journal
- Accession number :
- 11746601
- Full Text :
- https://doi.org/10.1002/yea.782