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BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2001 Dec 17; Vol. 194 (12), pp. 1823-34. - Publication Year :
- 2001
-
Abstract
- Plasmacytoid dendritic cells are present in lymphoid and nonlymphoid tissue and contribute substantially to both innate and adaptive immunity. Recently, we have described several monoclonal antibodies that recognize a plasmacytoid dendritic cell-specific antigen, which we have termed BDCA-2. Molecular cloning of BDCA-2 revealed that BDCA-2 is a novel type II C-type lectin, which shows 50.7% sequence identity at the amino acid level to its putative murine ortholog, the murine dendritic cell-associated C-type lectin 2. Anti-BDCA-2 monoclonal antibodies are rapidly internalized and efficiently presented to T cells, indicating that BDCA-2 could play a role in ligand internalization and presentation. Furthermore, ligation of BDCA-2 potently suppresses induction of interferon alpha/beta production in plasmacytoid dendritic cells, presumably by a mechanism dependent on calcium mobilization and protein-tyrosine phosphorylation by src-family protein-tyrosine kinases. Inasmuch as production of interferon alpha/beta by plasmacytoid dendritic cells is considered to be a major pathophysiological factor in systemic lupus erythematosus, triggering of BDCA-2 should be evaluated as therapeutic strategy for blocking production of interferon alpha/beta in systemic lupus erythematosus patients.
- Subjects :
- Amino Acid Sequence
Antibodies, Monoclonal immunology
Cloning, Molecular
Humans
Lectins genetics
Lectins immunology
Lupus Erythematosus, Systemic immunology
Membrane Glycoproteins
Molecular Sequence Data
Receptors, Immunologic
Receptors, Mitogen immunology
Antigen Presentation
Dendritic Cells immunology
Interferon-alpha immunology
Interferon-beta immunology
Lectins, C-Type
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1007
- Volume :
- 194
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 11748283
- Full Text :
- https://doi.org/10.1084/jem.194.12.1823