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Brain-derived neurotrophic factor alters cell migration of particular progenitors in the developing mouse cerebral cortex.
- Source :
-
Neuroscience letters [Neurosci Lett] 2002 Jan 04; Vol. 317 (1), pp. 21-4. - Publication Year :
- 2002
-
Abstract
- Effects of brain-derived neurotrophic factor (BDNF) on cell migration from the ventricular zone to the cortical plate (CP) in developing mouse cerebral cortex were examined. BDNF (700 ng) was injected into the brain ventricle of 13- or 14-day-old embryos (E13 or E14) after the intraperitoneal administration of 5-bromodeoxyuridine (BrdU) to pregnant mice. BDNF injection at E13 increased the number of BrdU-positive cells migrated into the CP until E15, and caused them to become localized in much deeper layers (V-VI) than expected (IV-V, as in the vehicle-treated mice) by postnatal day 1. However, when the injections were made at E14, BrdU-positive cells predominantly migrated to layers II/III irrespective of BDNF administration. These results demonstrate that BDNF affects particular progenitors at limited stages, and suggest the presence of a Reelin-independent mechanism(s) to regulate cell migration.
- Subjects :
- Animals
Body Patterning drug effects
Brain-Derived Neurotrophic Factor pharmacology
Bromodeoxyuridine
Cell Differentiation drug effects
Cell Division drug effects
Cell Division physiology
Cell Movement drug effects
Cerebral Cortex cytology
Cerebral Cortex drug effects
Female
Fetus
Gene Expression Regulation, Developmental drug effects
Gene Expression Regulation, Developmental physiology
Injections, Intraventricular
Mice
Mice, Inbred Strains
Neurons cytology
Neurons drug effects
Pregnancy
Reelin Protein
Stem Cells cytology
Stem Cells drug effects
Body Patterning physiology
Brain-Derived Neurotrophic Factor metabolism
Cell Differentiation physiology
Cell Movement physiology
Cerebral Cortex embryology
Neurons metabolism
Stem Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 317
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 11750987
- Full Text :
- https://doi.org/10.1016/s0304-3940(01)02412-0