Antigen presentation by murine peritoneal cavity macrophage-derived dendritic cells.

Authors :: Makala LH
Nishikawa Y
Kamada T
Xuan X
Nagasawa H
Source :: Pathobiology : journal of immunopathology, molecular and cellular biology [Pathobiology] 2001; Vol. 69 (2), pp. 104-12.
Publication Year :: 2001
Abstract: Murine peritoneal cavity macrophage derived dendritic cells (PEC-DC) generated using early growth factors, interleukin 4 and granulocyte-macrophage colony-stimulating factor followed by maturation in interferon-gamma plus either, Toxoplasma lysate antigen (TLA) or lipopolysaccharide, bind TLA by a nonspecific mechanism and continue to express major histocompatibility complex class II antigens after 24 h of culture in vitro. Moreover, the proliferation of CD3+ spleen T cells from mice immunized with Toxoplasma gondii homogenate, induced by PEC-DC-mediated antigen presentation was statistically significant and of consistent amplitude. This accessory function of PEC-DC is antigen specific.<br /> (Copyright 2001 S. Karger AG, Basel)

Language :: English
ISSN :: 1015-2008
Volume :: 69
Issue :: 2
Database :: MEDLINE
Journal :: Pathobiology : journal of immunopathology, molecular and cellular biology
Publication Type :: Academic Journal
Accession number :: 11752904
Full Text :: https://doi.org/10.1159/000048763

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