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Prevention of 6-hydroxydopamine neurotoxicity.

Authors :
Cohen G
Allis B
Winston B
Mytilineou C
Heikkila R
Source :
European journal of pharmacology [Eur J Pharmacol] 1975 Aug; Vol. 33 (1), pp. 217-21.
Publication Year :
1975

Abstract

1-Phenyl-3-(2-thiazolyl)-2-thiourea (PTTU) prevented the neurotoxic actions of 6-hydroxydopamine on adrenergic nerves in the mouse atrium and iris. This is the first reported 6-hydroxydopamine antagonist that does not act by blocking uptake of catecholamines into nerve terminals. PTTU also prevented the diabetogenic action of alloxan.

Subjects

Subjects :
Animals
Diabetes Mellitus, Experimental prevention & control
Heart Atria innervation
Heart Atria metabolism
Iris innervation
Iris metabolism
Male
Mice
Nerve Endings drug effects
Norepinephrine metabolism
Phenylthiazolylthiourea therapeutic use
Hydroxydopamines antagonists & inhibitors
Neurons drug effects
Phenylthiazolylthiourea pharmacology
Phenylthiourea analogs & derivatives
Sympathetic Nervous System drug effects

Details

Language :
English
ISSN :
0014-2999
Volume :
33
Issue :
1
Database :
MEDLINE
Journal :
European journal of pharmacology
Publication Type :
Academic Journal
Accession number :
1175689
Full Text :
https://doi.org/10.1016/0014-2999(75)90161-2
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