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The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear.
- Source :
-
Molecular and cellular biology [Mol Cell Biol] 2002 Feb; Vol. 22 (3), pp. 935-45. - Publication Year :
- 2002
-
Abstract
- Nor-1 belongs to the nur subfamily of nuclear receptor transcription factors. The precise role of Nor-1 in mammalian development has not been established. However, recent studies indicate a function for this transcription factor in oncogenesis and apoptosis. To examine the spatiotemporal expression pattern of Nor-1 and the developmental and physiological consequences of Nor-1 ablation, Nor-1-null mice were generated by insertion of the lacZ gene into the Nor-1 genomic locus. Disruption of the Nor-1 gene results in inner ear defects and partial bidirectional circling behavior. During early otic development, Nor-1 is expressed exclusively in the semicircular canal forming fusion plates. After formation of the membranous labyrinth, Nor-1 expression in the vestibule is limited to nonsensory epithelial cells localized at the inner edge of the semicircular canals and to the ampullary and utricular walls. In the absence of Nor-1, the vestibular walls fuse together as normal; however, the endolymphatic fluid space in the semicircular canals is diminished and the roof of the ampulla appears flattened due to defective continual proliferative growth of the semicircular canals.
- Subjects :
- Animals
Apoptosis genetics
Apoptosis physiology
Cell Division genetics
Cell Division physiology
DNA-Binding Proteins deficiency
DNA-Binding Proteins genetics
Epithelium embryology
Gene Expression Regulation, Developmental
Mice
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins deficiency
Nerve Tissue Proteins genetics
Postural Balance physiology
Receptors, Cytoplasmic and Nuclear deficiency
Receptors, Cytoplasmic and Nuclear genetics
Receptors, Steroid
Receptors, Thyroid Hormone
Semicircular Canals abnormalities
Semicircular Canals cytology
DNA-Binding Proteins physiology
Nerve Tissue Proteins physiology
Receptors, Cytoplasmic and Nuclear physiology
Semicircular Canals embryology
Subjects
Details
- Language :
- English
- ISSN :
- 0270-7306
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Molecular and cellular biology
- Publication Type :
- Academic Journal
- Accession number :
- 11784868
- Full Text :
- https://doi.org/10.1128/MCB.22.3.935-945.2002