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Parathyroid morphology in gerbils after thyroidectomy and calcium administration.
- Source :
-
Acta pathologica et microbiologica Scandinavica. Section A, Pathology [Acta Pathol Microbiol Scand A] 1975 Sep; Vol. 83 (5), pp. 539-49. - Publication Year :
- 1975
-
Abstract
- Morphological studies of the parathyroid glands from adult Mongolian gerbils in which hypercalcaemia had been induced by thyroidectomy and calcium injections for 2-19 days were carried out. The potassium pyro-antimonate technique and subsequent X-ray analysis of the precipitates were used for ultrastructural localization of cations. Ultrastructurally, most (suppressed) chief cells exhibited a dense cytoplasm, medium-sized or large mitochondria, glycogen particles, inconspicuous endoplasmic reticulum and Golgi complex, calcium-containing precipitates mainly in mitochondria and nuclei, and sometimes also lysosomal bodies and accumulations of secretory granules which occasionally seemed to be discharged into cytoplasmic vacuoles. A few parenchymal cells showed a low cytoplasmic density, few organelles, and structurally altered mitochondria, occasionally with associated smooth-surfaced vacuoles. These cells possessed calcium-containing precipitates in mitochondria, smooth-surfaced vacuoles, and also diffusely in the cytosol. It is concluded, that, in the main part of the parenchymal cells, the hypercalcaemia had resulted in a suppression primarily of the synthetic and later also of the secretory activity, and that the calcium-containing precipitation is different in the chief cell variants.
- Subjects :
- Animals
Cell Membrane drug effects
Cell Membrane ultrastructure
Cell Nucleus drug effects
Cell Nucleus ultrastructure
Cytoplasm drug effects
Cytoplasm ultrastructure
Cytoplasmic Granules drug effects
Cytoplasmic Granules ultrastructure
Endoplasmic Reticulum drug effects
Endoplasmic Reticulum ultrastructure
Female
Gerbillinae
Golgi Apparatus drug effects
Golgi Apparatus ultrastructure
Male
Mitochondria drug effects
Mitochondria ultrastructure
Parathyroid Glands drug effects
Calcium pharmacology
Parathyroid Glands ultrastructure
Thyroidectomy
Subjects
Details
- Language :
- English
- ISSN :
- 0365-4184
- Volume :
- 83
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta pathologica et microbiologica Scandinavica. Section A, Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 1180057
- Full Text :
- https://doi.org/10.1111/j.1699-0463.1975.tb00166.x