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Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease.
- Source :
-
Journal of the neurological sciences [J Neurol Sci] 2002 Feb 15; Vol. 194 (1), pp. 15-9. - Publication Year :
- 2002
-
Abstract
- Objective: The specificity of magnetic resonance imaging (MRI)-based hippocampal measurements in detecting Alzheimer's disease (AD) pathology is reduced by an age-related reduction of the hippocampus volume. We propose an adjustment for this age effect to increase the diagnostic accuracy of hippocampal volumes in AD.<br />Method: Using an orthogonal rotational transformation of the coordinate system, values of MRI-determined volumes of hippocampus-amygdala formation (HAF) were transformed according to the age effect in 27 AD patients and 28 age- and sex-matched healthy control subjects.<br />Results: The age transformation increased the diagnostic accuracy of HAF volumes in the study sample and in an independent sample from the literature. The age-transformed HAF volume predicted AD in a subject with mild cognitive impairment (MCI) with later biopsy-confirmed AD.<br />Conclusion: Age transformation may provide an easily applicable method to increase the clinical diagnostic accuracy of hippocampal measurements by considering the effect of aging on hippocampus volume.
- Subjects :
- Age Factors
Aged
Aging
Alzheimer Disease pathology
Biopsy
Discriminant Analysis
Female
Humans
Image Processing, Computer-Assisted methods
Male
Predictive Value of Tests
ROC Curve
Sensitivity and Specificity
Alzheimer Disease diagnosis
Amygdala pathology
Hippocampus pathology
Magnetic Resonance Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 0022-510X
- Volume :
- 194
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of the neurological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 11809161
- Full Text :
- https://doi.org/10.1016/s0022-510x(01)00669-4