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Transplantation of autologous retinal pigment epithelium in eyes with foveal neovascularization resulting from age-related macular degeneration: a pilot study.
- Source :
-
American journal of ophthalmology [Am J Ophthalmol] 2002 Feb; Vol. 133 (2), pp. 215-25. - Publication Year :
- 2002
-
Abstract
- Purpose: To describe the indications, surgical technique, and clinical results of 14 eyes in 13 patients with age-related macular degeneration and foveal choroidal neovascularization, in which subretinal surgery was combined with simultaneous transplantation of autologous retinal pigment epithelial cells.<br />Methods: Between March 1999 and February 2000, in a prospective study, 14 eyes (13 patients) with age-related macular degeneration underwent subretinal surgery because of foveal choroidal neovascularization with simultaneous transplantation of retinal pigment epithelium harvested from the nasal subretinal area of the same eye. Preoperatively, 1 month postoperatively, 3 months postoperatively and at 3-month intervals thereafter, examinations were performed including best-corrected visual acuity, visual field, biomicroscopy of anterior and posterior segment, tonometry, fluorescein and indocyanine angiographies, autofluorescence, scotometry, and fixation tests.<br />Results: Postoperatively, after median observation of 17 months (range, 12 to 24 months) best-corrected visual acuity was improved 2 or more lines in eight eyes (57.1%), remained the same (+/- 1 line) in five eyes (35%), and decreased by more than 2 lines in one eye (7.1%). Pairwise t test showed significant improvement after 1 month (P = .0031, P = .0062) as well as 1 year (P = .0066, P = .0105). Satisfactory reading vision between Jaeger 1 and 4 was achieved in three eyes (21.2%). No significant intraoperative or postoperative complications occurred in any eye. No recurrence of choroidal neovascularization was observed during the observation period.<br />Conclusions: In eyes with age-related macular degeneration and foveal choroidal neovascularization, autotransplantation of retinal pigment epithelium was performed in addition to conventional removal of the choroidal neovascularization without significant intraoperative or postoperative complications. Visual acuity improvement of 2 or more lines in 57% of the eyes was achieved. No recurrent choroidal neovascularization formation was observed during the observation period. The results of this pilot study suggest that autologous transplantation of retinal pigment epithelium combined with submacular surgery might be a reasonable treatment option for patients with foveal choroidal neovascularization secondary to age-related macular degeneration.
- Subjects :
- Aged
Aged, 80 and over
Choroidal Neovascularization diagnosis
Choroidal Neovascularization etiology
Female
Fluorescein Angiography
Fovea Centralis pathology
Humans
Macular Degeneration diagnosis
Male
Middle Aged
Ophthalmologic Surgical Procedures
Pigment Epithelium of Eye cytology
Pilot Projects
Prospective Studies
Tonometry, Ocular
Transplantation, Autologous
Treatment Outcome
Visual Acuity
Visual Fields
Cell Transplantation methods
Choroidal Neovascularization surgery
Fovea Centralis surgery
Macular Degeneration complications
Pigment Epithelium of Eye transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9394
- Volume :
- 133
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 11812425
- Full Text :
- https://doi.org/10.1016/s0002-9394(01)01373-3