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Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients.
- Source :
-
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2002 Feb; Vol. 26 (2), pp. 383-6. - Publication Year :
- 2002
-
Abstract
- The presence of the long (l) variant of the serotonin (5-hydroxytryptamine: 5-HT) transporter gene-linked polymorphic region (5-HTTLPR) is reported to be associated with a more favorable and faster antidepressant effect of selective serotonin reuptake inhibitors in Caucasians. The frequency of the l allele is lower in Japanese than in Caucasians; therefore, the antidepressant effect of fluvoxamine can be not as good in Japanese as in Caucasians. The authors investigated whether 5-HTTLPR was associated with the antidepressant response to fluvoxamine in 66 Japanese patients with major depressive disorder in a protocolized-dosing 6-week study. The short (s) allele frequency was significantly higher in the responsive individuals than in the nonresponsive ones (P = .010). The present study suggests that fluvoxamine is not less effective in depressive patients carrying the s allele than in the ones carrying the l allele and it is not less effective in Japanese than in Caucasians.
- Subjects :
- Adult
Aged
Alleles
Analysis of Variance
Chi-Square Distribution
Female
Gene Frequency genetics
Genetic Linkage drug effects
Genotype
Humans
Japan
Male
Middle Aged
Serotonin Plasma Membrane Transport Proteins
Antidepressive Agents therapeutic use
Carrier Proteins genetics
Depressive Disorder, Major drug therapy
Depressive Disorder, Major genetics
Fluvoxamine therapeutic use
Membrane Glycoproteins genetics
Membrane Transport Proteins
Nerve Tissue Proteins
Polymorphism, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0278-5846
- Volume :
- 26
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Progress in neuro-psychopharmacology & biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 11817517
- Full Text :
- https://doi.org/10.1016/s0278-5846(01)00287-1